For research use only. Not for therapeutic Use.
Ecadotril is a neutral endopeptidase (NEP) inhibitor. Ecadotril is the (S)-enantiomer of racecadotril. It acts as an antihypertensive.
| Catalog Number | R040526 |
| CAS Number | 112573-73-6 |
| Synonyms | N-[(2S)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine Phenylmethyl Ester; BAY-y 7432; BP 1.02; Ecadotril; S 049; |
| Molecular Formula | C21H23NO4S |
| Purity | ≥95% |
| Target | NEP Inhibitor |
| Storage | -20°C |
| IUPAC Name | benzyl 2-[[(2S)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate |
| InChI | InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)/t19-/m1/s1 |
| InChIKey | ODUOJXZPIYUATO-LJQANCHMSA-N |
| SMILES | CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2 |
| Reference | </br>1:Ecadotril. (S)-acetorphan, sinorphan. [No authors listed]Drugs R D. 1999 Apr;1(4):343-5. No abstract available. PMID: 10566059 </br>2:Prolonged inhibition of neutral endopeptidase 24.11 by sinorphan in stroke-prone spontaneously hypertensive rats. Stasch JP, Knorr A, Wegner M, Hirth-Dietrich C.Hypertens Res. 1995 Jun;18(2):137-43. PMID: 7584920 Free Article</br>3:[Effect of sinorphan, an endopeptidase inhibitor on severe congestive cardiac insufficiency]. Varin J, Duboc D, Weber S, Fouchard J, Schwartz JC, Muffat-Joly M, Guérin F.Arch Mal Coeur Vaiss. 1991 Oct;84(10):1465-71. Review. French. PMID: 1662033 </br>4:Effect of sinorphan, an enkephalinase inhibitor, on plasma atrial natriuretic factor and sodium urinary excretion in cirrhotic patients with ascites. Dussaule JC, Grangé JD, Wolf JP, Lecomte JM, Gros C, Schwartz JC, Bodin F, Ardaillou R.J Clin Endocrinol Metab. 1991 Mar;72(3):653-9. PMID: 1847706 </br>5:Antihypertensive activity of sinorphan. Lefrançois P, Clerc G, Duchier J, Lim C, Lecomte JM, Gros C, Schwartz JC.Lancet. 1990 Aug 4;336(8710):307-8. No abstract available. PMID: 1973988 </br>6:Effect of sinorphan on plasma atrial natriuretic factor in congestive heart failure. Kahn JC, Patey M, Dubois-Rande JL, Merlet P, Castaigne A, Lim-Alexandre C, Lecomte JM, Duboc D, Gros C, Schwartz JC.Lancet. 1990 Jan 13;335(8681):118-9. No abstract available. PMID: 1967410 |
