Siramesine hydrochloride

• CAT Number: I002725
• CAS Number: 224177-60-0
• Molecular Formula: C30H32ClFN2O
• Molecular Weight: 491.047
• Purity: ≥95%
• Target: sigma-2 receptor; lysosome-destabilizing agent
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: Store at -20C
• IUPAC Name: 1/'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4/'-piperidine];hydrochloride
• InChI: InChI=1S/C30H31FN2O.ClH/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30;/h1-4,8-15,21H,5-7,16-20,22H2;1H
• InChIKey: ILSRGIFRZZSGPN-UHFFFAOYSA-N
• SMILES: C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F.Cl

Siramesine hydrochloride (CAT: I002725) is a selective sigma-2 receptor agonist. It acts on sigma-2 receptors, found in various cell types, including cancer cells. By activating these receptors, Siramesine hydrochloride can induce cell death through mechanisms like apoptosis and autophagy. This compound has shown promise as an anticancer agent in preclinical studies, exhibiting antitumor effects in lung, breast, and prostate cancer. However, further research and clinical trials are needed to fully understand its therapeutic potential, efficacy, and safety in human patients.

Reference

[1]. Cesen MH, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818.
[2]. Spirkoski J, et al. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80.
[3]. Skuza G, et al. The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats. J Physiol Pharmacol. 2006 Jun;57(2):217-29.