For research use only, not for therapeutic use.
SIRT1-IN-1 (Cat No.:I015235) is a small molecule inhibitor of SIRT1, a histone deacetylase involved in various cellular processes such as gene expression, metabolism, and aging. SIRT1-IN-1 acts as a substrate-competitive inhibitor of SIRT1 with an IC50 value of 0.5 μM and shows selectivity over other sirtuin isoforms. SIRT1-IN-1 has been reported to exhibit potential therapeutic effects against several diseases such as cancer, inflammation, and diabetes by modulating SIRT1 activity.
| Catalog Number | I015235 |
| CAS Number | 352554-02-0 |
| Molecular Formula | C₁₄H₁₆N₂O |
| Purity | ≥95% |
| IUPAC Name | 6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| InChI | InChI=1S/C14H16N2O/c1-8-5-6-12-11(7-8)9-3-2-4-10(14(15)17)13(9)16-12/h5-7,10,16H,2-4H2,1H3,(H2,15,17) |
| InChIKey | KQWPYXBWZWLRMZ-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)NC3=C2CCCC3C(=O)N |
| Reference | [1]. Andrew D Napper, et al. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.<br>[2]. Thomas Shenk, et al. Sirtuin Modulators as Inhibitors of Cytomegalovirus. US20160296523A1. |
