SIRT1-IN-2

• CAT Number: I043676
• CAS Number: 2470969-89-0
• Molecular Formula: C13H15ClN2O
• Molecular Weight: 250.72
• Purity: ≥95%
• Synonyms: 2-(5-chloro-3-propan-2-yl-1H-indol-2-yl)acetamide
• InChI: InChI=1S/C13H15ClN2O/c1-7(2)13-9-5-8(14)3-4-10(9)16-11(13)6-12(15)17/h3-5,7,16H,6H2,1-2H3,(H2,15,17)
• InChIKey: IFPRJIBVYBLMFW-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(NC2=C1C=C(C=C2)Cl)CC(=O)N

SIRT1-IN-2 (compound 3h) is a potent and selective SIRT1 (silent information regulator 1) inhibitor, with an IC50 of 1.6 μM[1].
SIRT1-IN-2 (compound 3h) (0-100 μM, 48 h) inhibits the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, and shows significantly less cytotoxic on 293T cells and HUVEC[1].

Reference

[1]. Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561.
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