For research use only. Not for therapeutic Use.
SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1].
SIRT1-IN-3 (compound 3j) (0-100 μM, 48 h) inhibits the proliferation of human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, and shows low cytotoxic on 293T and HUVEC[1].
| Catalog Number | I043675 |
| CAS Number | 2470969-91-4 |
| Synonyms | 2-(5-bromo-3-propan-2-yl-1H-indol-2-yl)acetamide |
| Molecular Formula | C13H15BrN2O |
| Purity | ≥95% |
| InChI | InChI=1S/C13H15BrN2O/c1-7(2)13-9-5-8(14)3-4-10(9)16-11(13)6-12(15)17/h3-5,7,16H,6H2,1-2H3,(H2,15,17) |
| InChIKey | VBWIUUXBNGYYGO-UHFFFAOYSA-N |
| SMILES | CC(C)C1=C(NC2=C1C=C(C=C2)Br)CC(=O)N |
| Reference | [1]. Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561. |
