For research use only. Not for therapeutic Use.
SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC50 value of 18.5 μM[1].
SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC50 value of 118.4 μM[1].
SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells[1].
SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genes CDKN1A, PUMA and NOXA[1].
| Catalog Number | I042486 |
| CAS Number | 1005095-06-6 |
| Synonyms | 10-phenyl-9-azatetracyclo[10.2.1.02,11.03,8]pentadeca-3(8),4,6-triene-5-carboxamide |
| Molecular Formula | C21H22N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C21H22N2O/c22-21(24)15-8-9-17-16(11-15)18-13-6-7-14(10-13)19(18)20(23-17)12-4-2-1-3-5-12/h1-5,8-9,11,13-14,18-20,23H,6-7,10H2,(H2,22,24) |
| InChIKey | XALTUCOIORLBHQ-UHFFFAOYSA-N |
| SMILES | C1CC2CC1C3C2C4=C(C=CC(=C4)C(=O)N)NC3C5=CC=CC=C5 |
| Reference | [1]. Hoffmann G, et al. A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer. J Biol Chem. 2014 Feb 21;289(8):5208-16. |
