AGK2

• CAT Number: R014702
• CAS Number: 304896-28-4
• Molecular Formula: C₂₃H₁₃Cl₂N₃O₂
• Molecular Weight: 434.27
• Purity: ≥95%
• Synonyms: 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
• Target: Sirtuin
• Solubility: >9.3mg/mL in DMSO
• Storage: Store at +4C
• IUPAC Name: (E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide
• InChI: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
• InChIKey: SVENPFFEMUOOGK-SDNWHVSQSA-N
• SMILES: C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N

AGK2（Cat No.:R014702）is a selective inhibitor of SIRT2, a member of the sirtuin family of NAD+-dependent deacetylases involved in regulating cellular processes such as aging, metabolism, and neurodegeneration. By inhibiting SIRT2, AGK2 modulates the acetylation of key proteins, including α-tubulin and p53, impacting cell cycle regulation and apoptosis. AGK2 has shown promise in neurodegenerative disease research, particularly in models of Parkinson’s disease, where SIRT2 inhibition may protect neurons from toxicity. Its specificity for SIRT2 makes it a valuable tool for studying the role of sirtuins in disease and aging.