SIRT6-IN-1

• CAT Number: I036313
• CAS Number: 1214468-35-5
• Molecular Formula: C19H14N4O5S
• Molecular Weight: 410.404
• Purity: 98%
• Synonyms: SIRT6-IN-1
• Target: Cell Cycle/DNA Damage
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2,4-Dioxo-N-(4-(pyridin-3-yloxy)phenyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide
• InChI: InChI=1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
• InChIKey: CNILPKOOBRBNEQ-UHFFFAOYSA-N
• SMILES: O=S(C1=CC2=C(NC(NC2=O)=O)C=C1)(NC3=CC=C(OC4=CC=CN=C4)C=C3)=O

SIRT6-IN-1 is a novel SIRT6 inhibitor, reducing glycemia and improving oral glucose tolerance in unfed wild-type mice.