SIRT6-IN-2

• CAT Number: I036314
• CAS Number: 891002-11-2
• Molecular Formula: C19H14N2O6
• Molecular Weight: 366.32
• Purity: ≥95%
• Synonyms: 5-[[4-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid
• InChI: InChI=1S/C19H14N2O6/c22-15-8-7-13(10-14(15)19(25)26)21-17(23)11-3-5-12(6-4-11)20-18(24)16-2-1-9-27-16/h1-10,22H,(H,20,24)(H,21,23)(H,25,26)
• InChIKey: WCJCTRHTVZUWSD-UHFFFAOYSA-N
• SMILES: C1=COC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

SIRT6-IN-2 (CAT: I036314) is a selective inhibitor of Sirtuin 6 (SIRT6), an NAD⁺-dependent deacetylase involved in regulating genomic stability, metabolism, and inflammation. With an IC₅₀ of 34 μM, SIRT6-IN-2 increases acetylation of histone H3 at lysine 9 (H3K9) and enhances glucose uptake in cultured cells. Additionally, it reduces T cell proliferation, indicating potential immunosuppressive properties. Given its mechanism of action, SIRT6-IN-2 is most relevant to Metabolic Disease Research and Inflammation & Immunology Research, particularly in studies exploring metabolic regulation and immune responses.