SIRT6-IN-2

• CAT Number: I036314
• CAS Number: 891002-11-2
• Molecular Formula: C19H14N2O6
• Molecular Weight: 366.32
• Purity: ≥95%
• Synonyms: 5-[[4-(furan-2-carbonylamino)benzoyl]amino]-2-hydroxybenzoic acid
• InChI: InChI=1S/C19H14N2O6/c22-15-8-7-13(10-14(15)19(25)26)21-17(23)11-3-5-12(6-4-11)20-18(24)16-2-1-9-27-16/h1-10,22H,(H,20,24)(H,21,23)(H,25,26)
• InChIKey: WCJCTRHTVZUWSD-UHFFFAOYSA-N
• SMILES: C1=COC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)NC3=CC(=C(C=C3)O)C(=O)O

SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1].

Reference

[1]. Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858.
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