For research use only. Not for therapeutic Use.
SIS17（Cat No.:I018039）is a selective inhibitor of the protein kinase CK2, which plays a significant role in various cellular processes, including cell proliferation and survival. By targeting CK2, SIS17 disrupts its enzymatic activity, leading to altered signaling pathways that can induce apoptosis in cancer cells. This compound has shown promise in preclinical studies for its potential to inhibit tumor growth in various malignancies, including leukemia and solid tumors. Ongoing research aims to further elucidate its mechanisms of action and evaluate its efficacy and safety in clinical settings, positioning SIS17 as a potential therapeutic agent in oncology.
| Catalog Number | I018039 |
| CAS Number | 2374313-54-7 |
| Molecular Formula | C₂₁H₃₈N₂OS |
| Purity | ≥95% |
| Target | Epigenetics |
| IUPAC Name | N'-hexadecylthiophene-2-carbohydrazide |
| InChI | InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24) |
| InChIKey | HSHXDCVZWHOWCS-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1 |
| Reference | [1]. Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. |
