For research use only, not for therapeutic use.
SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
| Catalog Number | R060931 |
| CAS Number | 1009104-85-1 |
| Molecular Formula | C28H27N3O3 |
| Purity | ≥95% |
| Storage | 3 years -20°C powder |
| SMILES | COC1=CC2=C(CN(CC2)C(=O)C=CC3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC |
| Reference | [1] Jinnin M, et al. Mol Pharmacol. 2006 Feb;69(2):597-607. |
