SIS3

For research use only, not for therapeutic use.

  • CAT Number: R060931
  • CAS Number: 1009104-85-1
  • Molecular Formula: C28H27N3O3
  • Molecular Weight: 453.53
  • Purity: ≥95%
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SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.


Catalog Number R060931
CAS Number 1009104-85-1
Molecular Formula C28H27N3O3
Purity ≥95%
Storage 3 years -20°C powder
SMILES COC1=CC2=C(CN(CC2)C(=O)C=CC3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC
Reference

[1] Jinnin M, et al. Mol Pharmacol. 2006 Feb;69(2):597-607.

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