Sisapronil

• CAT Number: I009358
• CAS Number: 856225-89-3
• Molecular Formula: C15H6Cl2F8N4
• Molecular Weight: 465.13
• Purity: ≥95%
• Synonyms: Sisapronil; PF-0241851; PF 0241851; PF0241851.
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[2,2-difluoro-1-(trifluoromethyl)cyclopropyl]pyrazole-3-carbonitrile
• InChI: InChI=1S/C15H6Cl2F8N4/c16-6-1-5(14(20,21)22)2-7(17)10(6)29-11(27)9(8(3-26)28-29)12(15(23,24)25)4-13(12,18)19/h1-2H,4,27H2
• InChIKey: VBAVKJPWXSLDSG-UHFFFAOYSA-N
• SMILES: C1C(C1(F)F)(C2=C(N(N=C2C#N)C3=C(C=C(C=C3Cl)C(F)(F)F)Cl)N)C(F)(F)F

Sisapronil(CAT: I009358) is a potent non-steroidal antagonist of mineralocorticoid receptors (MRs). By competitively inhibiting MR activation, Sisapronil prevents the effects of aldosterone on sodium retention and potassium excretion, making it a valuable tool for studying mineralocorticoid-related pathways. It is widely used in research on hypertension, heart failure, and renal disorders where MR signaling plays a critical role. Sisapronil’s specificity enables detailed investigations into MR-mediated mechanisms and supports the development of novel therapies targeting aldosterone-driven pathologies.