For research use only. Not for therapeutic Use.
Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria[1][2].
Sisomicin (6.25 μg/mL) completely inhibits the growth of various clinical isolates bacterial, such as Klebsiella, Salmonella, Citrobacter, and Staphylococcus aureus[1].Sisomicin (20 μg/mL; 30 min) has insignificant impairment on polymorphonuclear neutrophil (PMN)[3].
Sisomicin (4 mg/kg; ip; single dose) appears to accumulate and persist in the kidneys, showing potential renal toxicity in rats[4].
| Catalog Number | R007647 |
| CAS Number | 32385-11-8 |
| Synonyms | (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol |
| Molecular Formula | C19H37N5O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H37N5O7/c1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17/h3,9-18,24-27H,4-7,20-23H2,1-2H3/t9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+/m1/s1 |
| InChIKey | URWAJWIAIPFPJE-YFMIWBNJSA-N |
| SMILES | CC1(COC(C(C1NC)O)OC2C(CC(C(C2O)OC3C(CC=C(O3)CN)N)N)N)O |
