Sisunatovir free base（Cat No.:I036316）, is a promising antiviral compound. It acts as an inhibitor of the fusion protein HR1 domain, specifically targeting respiratory syncytial virus (RSV) infections. Through its potent antiviral activity against RSV, Sisunatovir free base shows potential as a therapeutic option. It represents a new approach to combat RSV, a respiratory viral infection.
| Catalog Number | I036316 |
| CAS Number | 1903763-82-5 |
| Synonyms | RV521; RV-521; RV 521; Sisunatovir; |
| Molecular Formula | C23H22F4N4O |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | 1'-((5-(aminomethyl)-1-(4,4,4-trifluorobutyl)-1H-benzo[d]imidazol-2-yl)methyl)-6'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one |
| InChI | InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2 |
| InChIKey | JOPCJJSYRPUEDS-UHFFFAOYSA-N |
| SMILES | O=C1C2(CC2)C3=C(C=C(F)C=C3)N1CC4=NC5=C(N4CCCC(F)(F)F)C=CC(CN)=C5 |
| Reference | 1: Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c01882. Epub ahead of print. PMID: 33729773. |
