For research use only. Not for therapeutic Use.
Sisunatovir Free Base（Cat No.:I036316）is a potent antiviral compound used in the treatment of respiratory syncytial virus (RSV) infections. As a fusion inhibitor, it targets the RSV F protein, preventing viral entry into host cells. This mechanism helps reduce the severity and duration of RSV symptoms, particularly in vulnerable populations like infants and the elderly. Sisunatovir Free Base is currently being investigated in clinical trials for its effectiveness in managing RSV-related diseases. Its development offers a promising therapeutic option for respiratory infections caused by RSV.
| Catalog Number | I036316 |
| CAS Number | 1903763-82-5 |
| Synonyms | RV521; RV-521; RV 521; Sisunatovir; |
| Molecular Formula | C23H22F4N4O |
| Purity | 98% |
| Target | RSV |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one |
| InChI | InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2 |
| InChIKey | JOPCJJSYRPUEDS-UHFFFAOYSA-N |
| SMILES | C1CC12C3=C(C=C(C=C3)F)N(C2=O)CC4=NC5=C(N4CCCC(F)(F)F)C=CC(=C5)CN |
| Reference | 1: Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c01882. Epub ahead of print. PMID: 33729773. |
