For research use only. Not for therapeutic Use.
Sisunatovir HCl（Cat No.:I036317）is a high-purity hydrochloride salt form of a potent respiratory syncytial virus (RSV) fusion inhibitor. It is widely used in antiviral research for its ability to block RSV replication by targeting the fusion protein, crucial for viral entry into host cells. This compound is instrumental in studying RSV pathogenesis and developing therapies for respiratory infections. Sisunatovir HCl’s efficacy and specificity make it a valuable tool in virology and pharmaceutical research, aiding the discovery of innovative treatments for RSV and related respiratory viral diseases.
| Catalog Number | I036317 |
| CAS Number | 1903763-83-6 |
| Synonyms | RV521 hydrochloride; RV-521; RV 521; RV521; Sisunatovir HCl; Sisunatovir hydrochloride; |
| Molecular Formula | C23H23ClF4N4O |
| Purity | 98% |
| Target | RSV |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one;hydrochloride |
| InChI | InChI=1S/C23H22F4N4O.ClH/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27;/h2-5,10-11H,1,6-9,12-13,28H2;1H |
| InChIKey | NYYYAFKAHRIPJW-UHFFFAOYSA-N |
| SMILES | C1CC12C3=C(C=C(C=C3)F)N(C2=O)CC4=NC5=C(N4CCCC(F)(F)F)C=CC(=C5)CN.Cl |
| Reference | 1: Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MSA, Good JAD, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K. Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Mar 17. doi: 10.1021/acs.jmedchem.0c01882. Epub ahead of print. PMID: 33729773. |
