For research use only. Not for therapeutic Use.
Sitafloxacin Hydrate（Cat No.:A001015）is a broad-spectrum fluoroquinolone antibiotic used primarily for treating respiratory and urinary tract infections caused by susceptible bacteria. This hydrate form of Sitafloxacin enhances solubility and bioavailability, ensuring efficient therapeutic action. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication and repair. Its efficacy against both Gram-positive and Gram-negative pathogens, including multi-drug resistant strains, makes it valuable in combating complex infections. Sitafloxacin Hydrate is ideal for use in clinical settings requiring robust antimicrobial therapies for bacterial infections.
| Catalog Number | A001015 |
| CAS Number | 163253-35-8 |
| Synonyms | DU-6859a |
| Molecular Formula | C19H18ClF2N3O3.3/2H2O |
| Purity | ≥95% |
| Documentation | |
| Target | Bacterial |
| Storage | 3 years -20C powder |
| IUPAC Name | 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid;hydrate |
| InChI | InChI=1S/C19H18ClF2N3O3.H2O/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19;/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28);1H2/t10-,12+,13+;/m0./s1 |
| InChIKey | ANCJYRJLOUSQBW-JJZGMWGRSA-N |
| SMILES | C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)[C@@H]5C[C@@H]5F)F.O |
| Reference | Onodera, Y., Uchida, Y., Tanaka, M., & Sato, K. (1999). Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomeraseIV of Streptococcus pneumoniae. Journal Of Antimicrobial Chemotherapy, 44(4), 533-536. http://dx.doi.org/10.1093/jac/44.4.533</span></p> |
