For research use only. Not for therapeutic Use.
Sitafloxacin(Cat No.:I009498)is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair. This action prevents bacterial cell division, effectively eliminating the infection. Sitafloxacin demonstrates potent activity against Gram-negative and Gram-positive pathogens, including multi-drug resistant strains. It is commonly prescribed for respiratory tract infections, urinary tract infections, and skin infections. Due to its enhanced antibacterial profile, Sitafloxacin is considered a valuable option in combating difficult-to-treat infections.
Catalog Number | I009498 |
CAS Number | 127254-12-0 |
Synonyms | DU 6859; DU-6859; DU6859; DU 6859A; DU-6859A; DU6859A; Sitafloxacin; Sitafloxacin hydrate, Sitafloxacin anhydrous, Trade name: Gracevit.;7-((S)-7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroqui |
Molecular Formula | C19H18ClF2N3O3 |
Purity | ≥95% |
Target | Type II DNA topoisomerase |
Solubility | Soluble in DMSO |
Storage | RT |
IUPAC Name | 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid |
InChI | InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1 |
InChIKey | PNUZDKCDAWUEGK-CYZMBNFOSA-N |
SMILES | C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)[C@@H]5C[C@@H]5F)F |
Reference | 1. Drugs Today (Barc). 2008 Jul;44(7):489-501. doi: 10.1358/dot.2008.44.7.1219561. |