Sitagliptin Phosphate Monohydrate

• CAT Number: A000525
• CAS Number: 654671-77-9
• Molecular Formula: C₁₆H₁₅F₆N₅O•H₃PO₄•H₂O
• Molecular Weight: 523.32
• Purity: ≥95%
• Synonyms: MK-0431
• Target: DPP-4
• Solubility: >23.8mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric acid;hydrate
• InChI: InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
• InChIKey: GQPYTJVDPQTBQC-KLQYNRQASA-N
• SMILES: C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N.O.OP(=O)(O)O

Sitagliptin Phosphate Monohydrate（Cat No.:A000525）is an oral antidiabetic drug that functions as a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, effectively managing type 2 diabetes by increasing incretin hormone levels. This inhibition prolongs the action of hormones like GLP-1, which stimulates insulin release and decreases glucagon levels post-meal, helping regulate blood glucose. Known for its low hypoglycemia risk, sitagliptin phosphate monohydrate is often used alongside other antidiabetic medications for enhanced glycemic control. Its favorable safety profile and once-daily dosing make it a reliable option for long-term diabetes management.