sitaxsentan

• CAT Number: I002384
• CAS Number: 184036-34-8
• Molecular Formula: C18H15ClN2O6S2
• Molecular Weight: 454.91
• Purity: ≥95%
• Synonyms: N-(4-chloro-3-methylisoxazol-5-yl)-2-(2-(6-methylbenzo[d][1,3]dioxol-5-yl)acetyl)thiophene-3-sulfonamide
• Target: Endothelin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-(4-chloro-3-methyl-1,2-oxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide
• InChI: InChI=1S/C18H15ClN2O6S2/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18/h3-5,7,21H,6,8H2,1-2H3
• InChIKey: PHWXUGHIIBDVKD-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)NC4=C(C(=NO4)C)Cl)OCO2

Sitaxsentan(CAT: I002384) is a potent and selective endothelin receptor A (ETA) antagonist, primarily used in cardiovascular and pulmonary research. By selectively blocking ETA receptors, it reduces the effects of endothelin-1, a potent vasoconstrictor, leading to vasodilation and decreased pulmonary arterial pressure. This mechanism makes Sitaxsentan a valuable tool for studying conditions like pulmonary arterial hypertension (PAH) and other vascular disorders. Its high selectivity for ETA receptors also allows researchers to explore the role of endothelin pathways in vascular remodeling, right heart dysfunction, and systemic hypertension, providing critical insights into therapeutic strategies for cardiovascular diseases.