Sitravatinib

• CAT Number: I000466
• CAS Number: 1123837-84-2
• Molecular Formula: C33H29F2N5O4S
• Molecular Weight: 629.68
• Purity: ≥95%
• Synonyms: MGCD516; MG-516
• Target: RTK inhibitor
• Solubility: DMSO ≥ 32 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 1-N'-[3-fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
• InChI: InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)
• InChIKey: WLAVZAAODLTUSW-UHFFFAOYSA-N
• SMILES: COCCNCC1=CN=C(C=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

Sitravatinib(CAT: I000466) is a novel small molecule inhibitor that targets multiple receptor tyrosine kinases (RTKs) involved in driving sarcoma cell growth. RTKs are a family of cell surface receptors that play a critical role in various cellular processes, including cell growth, proliferation, and survival. By inhibiting these RTKs, sitravatinib disrupts the signaling pathways that promote the growth of sarcoma cells. This targeted approach makes sitravatinib a potential therapeutic option for the treatment of sarcomas, a diverse group of malignant tumors arising from mesenchymal tissues.

Reference

1:Oncotarget. 2016 Jan 26;7(4):4093-109. doi: 10.18632/oncotarget.6547. Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma.Patwardhan PP,Ivy KS,Musi E,de Stanchina E,Schwartz GK, PMID: 26675259 PMCID: PMC4826192 DOI: 10.18632/oncotarget.6547
Abstract: Sarcomas are rare but highly aggressive mesenchymal tumors with a median survival of 10-18 months for metastatic disease. Mutation and/or overexpression of many receptor tyrosine kinases (RTKs) including c-Met, PDGFR, c-Kit and IGF1-R drive defective signaling pathways in sarcomas. MGCD516 (Sitravatinib) is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth. In the present study, we evaluated the efficacy of MGCD516 both in vitro and in mouse xenograft models in vivo. MGCD516 treatment resulted in significant blockade of phosphorylation of potential driver RTKs and induced potent anti-proliferative effects in vitro. Furthermore, MGCD516 treatment of tumor xenografts in vivo resulted in significant suppression of tumor growth. Efficacy of MGCD516 was superior to imatinib and crizotinib, two other well-studied multi-kinase inhibitors with overlapping target specificities, both in vitro and in vivo. This is the first report describing MGCD516 as a potent multi-kinase inhibitor in different models of sarcoma, superior to imatinib and crizotinib. Results from this study showing blockade of multiple driver signaling pathways provides a rationale for further clinical development of MGCD516 for the treatment of patients with soft-tissue sarcoma.