For research use only. Not for therapeutic Use.
Sivelestat（Cat No.:I001094）is a selective inhibitor of neutrophil elastase, used primarily in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). By inhibiting neutrophil elastase, it reduces inflammation and tissue damage in the lungs, improving respiratory function. Its high specificity and efficacy make it valuable in clinical settings for managing severe inflammatory conditions. Sivelestat is essential for reducing mortality and morbidity in patients with ALI and ARDS, contributing significantly to advancements in critical care and therapeutic strategies for inflammatory lung diseases.
| Catalog Number | I001094 |
| CAS Number | 127373-66-4 |
| Synonyms | 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetic acid |
| Molecular Formula | C20H22N2O7S |
| Purity | ≥95% |
| Target | Elastase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 44 nM |
| IUPAC Name | 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid |
| InChI | InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) |
| InChIKey | BTGNGJJLZOIYID-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O |
