For research use only. Not for therapeutic Use.
Sivelestat sodium（Cat No.:I001861）is a selective neutrophil elastase inhibitor primarily used to manage acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) in intensive care settings. By inhibiting neutrophil elastase, sivelestat reduces inflammation and tissue damage in the lungs, helping to prevent the degradation of elastin and other structural proteins in pulmonary tissue. Its anti-inflammatory properties are beneficial in conditions with excessive neutrophil activation, limiting the progression of lung injury. Sivelestat sodium’s targeted action provides a therapeutic option for patients with severe inflammatory respiratory conditions.
| Catalog Number | I001861 |
| CAS Number | 150374-95-1 |
| Synonyms | sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate |
| Molecular Formula | C20H21N2NaO7S |
| Purity | ≥95% |
| Target | Anti-infection |
| Solubility | 10 mM in DMSO |
| Storage | Desiccate at RT |
| IC50 | 44 nM |
| IUPAC Name | sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate |
| InChI | InChI=1S/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1 |
| InChIKey | ZAIFANJZUGNYCK-UHFFFAOYSA-M |
| SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+] |
| Reference | <p style=/line-height:25px/> |
