Sivelestat sodium tetrahydrate

• CAT Number: I002548
• CAS Number: 201677-61-4
• Molecular Formula: C20H21N2O7S • Na [4H2O]
• Molecular Weight: 528.50
• Purity: ≥95%
• Synonyms: LY544349;ONO-5046
• Target: Anti-infection
• Solubility: DMSO: 10 mg/mL
• Storage: -20°C
• IC50: 44 nM
• IUPAC Name: sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate;tetrahydrate
• InChI: InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1
• InChIKey: PLHREJBSQUSUCW-UHFFFAOYSA-M
• SMILES: CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+]

Sivelestat sodium tetrahydrate（Cat No.:I002548）is a selective inhibitor of neutrophil elastase, an enzyme involved in inflammatory processes and tissue damage. By inhibiting neutrophil elastase, sivelestat reduces inflammation and protects tissues from damage caused by excessive neutrophil activity, particularly in conditions like acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). It has shown potential in reducing pulmonary inflammation and improving outcomes in preclinical and clinical studies. Sivelestat’s therapeutic applications are focused on managing inflammatory conditions, making it a valuable agent in respiratory and critical care medicine.

Reference

[1]. Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
[2]. Imokawa S, et al. Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate. Nihon Kokyuki Gakkai Zasshi. 2008 Jun;46(6):461-5.