For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.<br>IC50 value: 0.84 uM(EC50) [1]<br>Target: MDMX inhibitor<br>in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX protein by covalent binding in our FP assay buffer. MDMX-p53 interaction was at least partially inhibited by SJ-172550, despite its relatively low cell permeability [1]. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53 [2].</p>
| Catalog Number | I003540 |
| CAS Number | 431979-47-4 |
| Synonyms | methyl 2-[2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy]acetate |
| Molecular Formula | C22H21ClN2O5 |
| Purity | ≥95% |
| Target | MDM-2/p53; E1/E2/E3 Enzyme |
| Solubility | 10 mM in DMSO |
| Storage | Store at 4°C |
| IC50 | 0.84 uM(EC50) [1] |
| InChIKey | RKKFQJXGAQWHBZ-YVLHZVERSA-N |
| Reference | <p style=/line-height:25px/> |
