For research use only. Not for therapeutic Use.
SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1].
SJ572403 (SJ403) (3 mM) shows specific interactions with specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM[1].
SJ572403 (0-3 mM) modulates p27’s Cdk regulatory[1].
SJ572403 (10 μM-3 mM) displaces p27-D2 from Cdk2/cyclin A and partially restores Cdk2 kinase activity[1].
| Catalog Number | I019319 |
| CAS Number | 19970-45-7 |
| Synonyms | 6-ethyl-2,4,7,8-tetramethylpurino[7,8-a]imidazole-1,3-dione |
| Molecular Formula | C13H17N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H17N5O2/c1-6-17-7(2)8(3)18-9-10(14-12(17)18)15(4)13(20)16(5)11(9)19/h6H2,1-5H3 |
| InChIKey | JKJLETUKWLALKV-UHFFFAOYSA-N |
| SMILES | CCN1C(=C(N2C1=NC3=C2C(=O)N(C(=O)N3C)C)C)C |
| Reference | [1]. Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1). Sci Rep. 2015 Oct 28;5:15686. [2]. Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60(10):5003-5010. |
