SJ6986

• CAT Number: I036327
• CAS Number: 2765625-93-0
• Molecular Formula: C20H14F3N3O7S
• Molecular Weight: 497.40
• Purity: 98%
• Synonyms: SJ6986; SJ-6986; SJ 6986
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
• InChI: InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28)
• InChIKey: RKAFYSIKAVFVPS-UHFFFAOYSA-N
• SMILES: O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O

SJ6986(CAT: I036327) is a potent, selective, and orally bioavailable small-molecule degrader targeting GSPT1/2, derived from a focused library of cereblon modulators. By leveraging cereblon-dependent proteasomal degradation, it facilitates the targeted removal of GSPT1/2 proteins, making it particularly valuable in oncology and drug discovery research. This compound provides a powerful tool for exploring the role of GSPT1/2 in cell cycle regulation and tumor progression, offering insights into novel therapeutic strategies. SJ6986 exemplifies the precision of targeted protein degradation, supporting advancements in PROTAC® technology and personalized medicine.