For research use only. Not for therapeutic Use.
SJ988497（Cat No.:I042461）is a potent and selective inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a crucial role in converting inactive cortisone to its active form, cortisol. By inhibiting 11β-HSD1, SJ988497 may help modulate cortisol levels, potentially offering therapeutic benefits for metabolic disorders, such as obesity, type 2 diabetes, and metabolic syndrome. This compound is being investigated for its potential to improve insulin sensitivity and reduce inflammation, making it a promising candidate in the treatment of disorders related to glucocorticoid excess and metabolic dysfunction.
| CAS Number | 2595365-41-4 |
| Synonyms | N-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butyl]-4-[[4-(1-propylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]benzamide |
| Molecular Formula | C36H36N10O5 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butyl]-4-[[4-(1-propylpyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]benzamide |
| InChI | InChI=1S/C36H36N10O5/c1-2-18-45-20-22(19-40-45)30-25-14-17-38-31(25)44-36(43-30)41-23-10-8-21(9-11-23)32(48)39-16-4-3-15-37-26-7-5-6-24-29(26)35(51)46(34(24)50)27-12-13-28(47)42-33(27)49/h5-11,14,17,19-20,27,37H,2-4,12-13,15-16,18H2,1H3,(H,39,48)(H,42,47,49)(H2,38,41,43,44) |
| InChIKey | MPFPDTOOHBZQJD-UHFFFAOYSA-N |
| SMILES | CCCN1C=C(C=N1)C2=C3C=CNC3=NC(=N2)NC4=CC=C(C=C4)C(=O)NCCCCNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
