SJB2-043

• CAT Number: I004390
• CAS Number: 63388-44-3
• Molecular Formula: C17H9NO3
• Molecular Weight: 275.26
• Purity: ≥95%
• Synonyms: 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
• Target: Deubiquitinase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.544 uM (USP1) [1]
• InChI: 1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
• InChIKey: CMYQQADDUUDCCA-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O

SJB2-043 (Cat No.: I004390) is a potent and selective inhibitor of USP1 (ubiquitin-specific protease 1), an enzyme involved in DNA damage repair and protein homeostasis. By inhibiting USP1, SJB2-043 disrupts the Fanconi anemia (FA) pathway, making it a valuable tool in cancer research, particularly for enhancing the efficacy of DNA-damaging chemotherapies. It has shown promise in targeting tumor cells with defective DNA repair mechanisms, such as those in certain leukemias and solid tumors. Its role in modulating ubiquitin signaling makes it a key compound in drug discovery.

Reference

[1]. Helena Mistry, Grace Hsieh, Sara S. Buhrlage, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013.