For research use only. Not for therapeutic Use.
SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.
SJB3-019A (IC50=0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity[1].
| Catalog Number | I046398 |
| CAS Number | 2070015-29-9 |
| Synonyms | 2-pyridin-3-ylbenzo[f][1,3]benzoxazole-4,9-dione |
| Molecular Formula | C16H8N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H8N2O3/c19-13-10-5-1-2-6-11(10)14(20)15-12(13)18-16(21-15)9-4-3-7-17-8-9/h1-8H |
| InChIKey | DOYPPVCQHGJUBC-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)OC(=N3)C4=CN=CC=C4 |
| Reference | [1]. Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013. |
