For research use only. Not for therapeutic Use.
SK-216 is a specific inhibitor of PAI-1 and limits tumor progression and angiogenesis. SK-216 could suppress PAI-1 expression in rat colon cancer cells as well as intestinal polyp formation in a Min mouse. Furthermore, SK-216 could inhibit lung metastasis of human lung cancer cells and mouse melanoma cells in an intravenously-injected mouse mode. Potential novel anti-metastasis agent for human osteosarcoma.
KEYWORDS: SK-216 | supplier | PAI-1 inhibitor | SK216 | SK 216 | CAS [654080-02-1] | [654080-03-2] | Serpin | Plasminogen activator inhibitor-1 (PAI-1) | Inhibitor | Enzymes
| Catalog Number | I047632 |
| CAS Number | 654080-02-1 |
| Molecular Formula | C29H31NO6 |
| Purity | ≥95% |
| IUPAC Name | 2-[5-[6-(5-tert-butyl-1,3-benzoxazol-2-yl)naphthalen-2-yl]oxypentyl]propanedioic acid |
| InChI | InChI=1S/C29H31NO6/c1-29(2,3)21-11-13-25-24(17-21)30-26(36-25)20-9-8-19-16-22(12-10-18(19)15-20)35-14-6-4-5-7-23(27(31)32)28(33)34/h8-13,15-17,23H,4-7,14H2,1-3H3,(H,31,32)(H,33,34) |
| SMILES | CC(C)(C)C1=CC2=C(C=C1)OC(=N2)C3=CC4=C(C=C3)C=C(C=C4)OCCCCCC(C(=O)O)C(=O)O |
| Reference | M Mutoh et al. Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis. 2008 Apr;29(4):824-9. T Masuda et al. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol Cancer Ther. 2013 Nov;12(11):2378-88. M Tsuge et al. SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma. Int J Mol Sci. 2018 Mar 5;19(3). pii: E736. |
