SKA-111

• CAT Number: I036342
• CAS Number: 1369170-24-0
• Molecular Formula: C12H10N2S
• Molecular Weight: 214.29
• Purity: ≥95%
• Synonyms: 5-methylbenzo[e][1,3]benzothiazol-2-amine
• InChI: InChI=1S/C12H10N2S/c1-7-6-10-11(14-12(13)15-10)9-5-3-2-4-8(7)9/h2-6H,1H3,(H2,13,14)
• InChIKey: JQZQMZXXJFFVFE-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C3=CC=CC=C13)N=C(S2)N

SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research[1].
SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin (HY-P0206)-induced coronary dilations in the isolated rat heart[1].