Skepinone-L

• CAT Number: I000850
• CAS Number: 1221485-83-1
• Molecular Formula: C₂₄H₂₁F₂NO₄
• Molecular Weight: 425.40
• Purity: ≥95%
• Synonyms: 3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one
• Target: p38
• Solubility: in DMSO > 10 mM
• Storage: Store at -20°C
• IUPAC Name: 13-(2,4-difluoroanilino)-5-[(2R)-2,3-dihydroxypropoxy]tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one
• InChI: InChI=1S/C24H21F2NO4/c25-16-4-8-23(22(26)10-16)27-17-5-7-20-15(9-17)2-1-14-3-6-19(11-21(14)24(20)30)31-13-18(29)12-28/h3-11,18,27-29H,1-2,12-13H2/t18-/m1/s1
• InChIKey: HXMGCTFLLWPVFM-GOSISDBHSA-N
• SMILES: C1CC2=C(C=CC(=C2)NC3=C(C=C(C=C3)F)F)C(=O)C4=C1C=CC(=C4)OC[C@@H](CO)O

Skepinone-L（Cat No.:I000850）is a selective inhibitor of p38 MAPK, specifically targeting the p38α isoform. It has been widely used in research to study inflammation-related signaling pathways, as p38 MAPK plays a key role in immune responses, cell differentiation, and apoptosis. Skepinone-L effectively blocks the production of pro-inflammatory cytokines, making it a valuable compound in preclinical studies investigating inflammatory diseases, such as rheumatoid arthritis and psoriasis. Its high selectivity and potency offer a precise tool for exploring the therapeutic potential of targeting p38α MAPK in various disease models.

Reference

[1]. Koeberle, Solveigh C.; Romir, Johannes; Fischer, Stefan et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nature Chemical Biology (2012), 8(2), 141-143.
[2]. Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter et al. Design, Synthesis, and Biological Evaluation of Novel Disubstituted Dibenzosuberones as Highly Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Journal of Medicinal Chemistry (2012), 55(12), 5868-5877.