For research use only. Not for therapeutic Use.
SKF-75670 hydrochloride is a Dopamine D1 receptor partial agonist. SKF-75670 hydrochloride is also a Cocaine antagonist[1][2][3].
SKF-75670 hydrochloride (2.5-10 mg/kg, i.p.) reduces locomotor activity in MPTP-treated marmosets[2].
SKF-75670 hydrochloride (0.3 and 1.0 mg/kg, i.m.) antagonizes the rate-altering and discriminative-stimulus effects of Cocaine in monkeys[3].
| Catalog Number | I009506 |
| CAS Number | 62717-63-9 |
| Synonyms | 3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrobromide |
| Molecular Formula | C17H20BrNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H19NO2.BrH/c1-18-8-7-13-9-16(19)17(20)10-14(13)15(11-18)12-5-3-2-4-6-12;/h2-6,9-10,15,19-20H,7-8,11H2,1H3;1H |
| InChIKey | KWTPHNVUAVFKGB-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O.Br |
| Reference | [1]. Rosenzweig-Lipson S, et al. Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75. [2]. Gnanalingham KK, et al. Differential anti-parkinsonian effects of benzazepine D1 dopamine agonists with varying efficacies in the MPTP-treated common marmoset. Psychopharmacology (Berl). 1995 Feb;117(3):275-86. [3]. Spealman RD, et al. Differential modulation of behavioral effects of cocaine by low- and high-efficacy D1 agonists. Psychopharmacology (Berl). 1997 Oct;133(3):283-92. |
