SKF 81297

• CAT Number: I040636
• CAS Number: 71636-61-8
• Molecular Formula: C16H16ClNO2
• Molecular Weight: 289.76
• Purity: ≥95%
• Synonyms: 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
• InChI: InChI=1S/C16H16ClNO2/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H2
• InChIKey: GHWJEDJMOVUXEC-UHFFFAOYSA-N
• SMILES: C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3

SKF 81297 (Cat No.: I040636) is a potent and selective dopamine D₁-like receptor agonist, primarily targeting the D₁ and D₅ subtypes. It is widely used in neuropharmacological research to study dopaminergic signaling, motor control, and cognitive processes. By stimulating D₁ receptors, SKF 81297 increases intracellular cAMP levels, influencing neuronal excitability and synaptic plasticity. It has been used in models of Parkinson’s disease, schizophrenia, and addiction, helping to elucidate the role of D₁ receptors in central nervous system function and neuropsychiatric disorders.

Reference

[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7.
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[2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.
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