For research use only. Not for therapeutic Use.
SKF 81297 is a potent and selective dopamine D1 receptor agonist[1].
SKF 81297 (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1].
| Catalog Number | I040636 |
| CAS Number | 71636-61-8 |
| Synonyms | 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol |
| Molecular Formula | C16H16ClNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H16ClNO2/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20/h1-5,8,13,18-20H,6-7,9H2 |
| InChIKey | GHWJEDJMOVUXEC-UHFFFAOYSA-N |
| SMILES | C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3 |
| Reference | [1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844. |
