For research use only. Not for therapeutic Use.
SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1].
SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate[2].
SKF-82958 hydrobromide (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].
| Catalog Number | I004752 |
| CAS Number | 74115-01-8 |
| Synonyms | 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol;hydrobromide |
| Molecular Formula | C19H21BrClNO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H |
| InChIKey | WLXGFAVTAAQOFH-UHFFFAOYSA-N |
| SMILES | C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl.Br |
| Reference | [1]. Mottola DM, et al. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. J Med Chem. 1996;39(1):285-296. [2]. Haile CN, et al. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388(2):125-131. [3]. Mayorga AJ, et al. Striatal and nigral D1 mechanisms involved in the antiparkinsonian effects of SKF 82958 (APB): studies of tremulous jaw movements in rats. Psychopharmacology (Berl). 1999;143(1):72-81. |
