SKF-86002

• CAT Number: I004712
• CAS Number: 72873-74-6
• Molecular Formula: C₁₆H₁₂F₃FS
• Molecular Weight: 297.35
• Purity: ≥95%
• Target: p38 MAPK
• Solubility: 10 mM in DMSO
• Storage: Store at RT
• IUPAC Name: 6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole
• InChI: InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
• InChIKey: YOELZIQOLWZLQC-UHFFFAOYSA-N
• SMILES: C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F

SKF-86002(CAT: I004712) is a potent inhibitor of p38 MAP kinase, exhibiting an IC50 of 0.5–1 μM. By targeting p38 MAP kinase, it disrupts key signaling pathways involved in inflammation and stress responses. SKF-86002 has been widely used in research to investigate the role of p38 MAP kinase in inflammatory diseases, cancer, and other pathological conditions driven by aberrant kinase activity. Its specificity and efficacy make it a valuable tool for studying MAP kinase signaling and for the development of therapeutic strategies targeting this critical pathway.