For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).<br>IC50 value:<br>Target: p38 MAPK inhibitor<br>in vitro: SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP [3].</p>
| Catalog Number | I004712 |
| CAS Number | 72873-74-6 |
| Molecular Formula | C₁₆H₁₂F₃FS |
| Purity | ≥95% |
| Target | p38 MAPK |
| Solubility | 10 mM in DMSO |
| Storage | Store at RT |
| InChI | InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2 |
| InChIKey | YOELZIQOLWZLQC-UHFFFAOYSA-N |
| SMILES | C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| Reference | <p style=/line-height:25px/> |
