SKF 91488 dihydrochloride

• CAT Number: I010224
• CAS Number: 68941-21-9
• Molecular Formula: C7H19Cl2N3S
• Molecular Weight: 248.21
• Purity: ≥95%
• Synonyms: 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
• Target: Transferase
• Solubility: Soluble to 75 mM in DMSO
• Storage: Desiccate at RT
• IUPAC Name: 4-(dimethylamino)butyl carbamimidothioate;dihydrochloride
• InChI: InChI=1S/C7H17N3S.2ClH/c1-10(2)5-3-4-6-11-7(8)9;;/h3-6H2,1-2H3,(H3,8,9);2*1H
• InChIKey: NPLHSMBWWIIWAQ-UHFFFAOYSA-N
• SMILES: CN(C)CCCCSC(=N)N.Cl.Cl

SKF 91488 Dihydrochloride(CAT: I010224) is a potent and selective histamine N-methyltransferase (HMT) inhibitor, structurally related to dimaprit but lacking histamine agonist activity. By inhibiting HMT, it prevents the breakdown of histamine, thereby increasing histamine levels without directly stimulating histamine receptors. This makes SKF 91488 a valuable tool in neuropharmacology and immunology research for studying histamine-mediated signaling pathways, allergic responses, and neuroinflammatory processes. Its selective inhibition of histamine degradation allows researchers to explore the physiological and pathological roles of histamine in immune responses, sleep regulation, and neurological disorders.