For research use only. Not for therapeutic Use.
SKF-96365 hydrochloride (CAT: I001169) is a pharmacological agent that acts as a non-selective inhibitor of store-operated calcium channels (SOCs). It blocks the influx of calcium ions into cells by inhibiting the opening of SOC channels, which are essential for calcium signaling and regulation of various cellular processes. SKF-96365 hydrochloride has been widely used in research to investigate the roles of calcium channels in cellular functions, such as neurotransmission, smooth muscle contraction, immune response, and cell proliferation. It has also been explored as a potential therapeutic target for various conditions, including cardiovascular diseases, neurodegenerative disorders, and cancer.
| Catalog Number | I001169 |
| CAS Number | 130495-35-1 |
| Synonyms | SKF96365 hydrochloride; |
| Molecular Formula | C22H26N2O3 • HCl |
| Purity | ≥95% |
| Target | TRP Channel |
| Solubility | >20 mg/mL in DMSO |
| Storage | Store at RT |
| InChI | InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H |
| InChIKey | FWLPKVQUECFKSW-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C(OCCCC2=CC=C(OC)C=C2)CN3C=NC=C3.Cl |
| Reference | </br>1:Multiple effects of 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF 96365) on Ca2+ signaling in MDCK cells: depletion of thapsigargin-sensitive Ca2+ store followed by capacitative Ca2+ entry, activation of a direct Ca2+ entry, and inhibition of thapsigargin-induced capacitative Ca2+ entry. Jan CR, Ho CM, Wu SN, Tseng CJ.Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):92-101. PMID: 10048593 </br>2:SK&F 96365 (1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenylethyl]-1H- imidazole hydrochloride) stimulates phosphoinositide hydrolysis in human U373 MG astrocytoma cells. Arias-Montaño JA, Gibson WJ, Young JM.Biochem Pharmacol. 1998 Oct 15;56(8):1023-7. PMID: 9776313 |
