For research use only. Not for therapeutic Use.
Skullcapflavone II（Cat No.:I014874）is a flavonoid compound derived from Scutellaria baicalensis, known for its anti-inflammatory and antibacterial properties. It plays a role in regulating the differentiation, survival, and function of osteoclasts, cells responsible for bone resorption. Additionally, Skullcapflavone II exhibits potent antibacterial activity against Mycobacterium aurum and Mycobacterium bovis BCG. These findings suggest that Skullcapflavone II has therapeutic potential in conditions involving inflammation, bone remodeling, and bacterial infections, highlighting its multifaceted pharmacological effects.
| Catalog Number | I014874 |
| CAS Number | 55084-08-7 |
| Molecular Formula | C₁₉H₁₈O₈ |
| Purity | ≥95% |
| Target | Bacterial |
| IUPAC Name | 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxychromen-4-one |
| InChI | InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8,20,22H,1-4H3 |
| InChIKey | GMQFOKBGMKVUQZ-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC(=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O)O |
| Reference | [1]. Solnier J, et al. Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules. 2020;25(3):734. Published 2020 Feb 7.<br>[2]. Lee J, et al. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling. FASEB J. 2019;33(2):2026-2036.<br>[3]. Jang HY, et al. Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma [published correction appears in Int Immunopharmacol. 2013 Sep;17(1):154]. Int Immunopharmacol. 2012;12(4):666-674. |
