SLB1122168 formic

• CAT Number: I040826
• Molecular Formula: C23H37N3O3
• Molecular Weight: 403.56
• Purity: ≥95%
• Synonyms: 6-decyl-N-[[(3S)-pyrrolidin-3-yl]methyl]-1,3-benzoxazol-2-amine;formic acid
• InChI: InChI=1S/C22H35N3O.CH2O2/c1-2-3-4-5-6-7-8-9-10-18-11-12-20-21(15-18)26-22(25-20)24-17-19-13-14-23-16-19;2-1-3/h11-12,15,19,23H,2-10,13-14,16-17H2,1H3,(H,24,25);1H,(H,2,3)/t19-;/m0./s1
• InChIKey: NCROFXPTZAVBIP-FYZYNONXSA-N
• SMILES: CCCCCCCCCCC1=CC2=C(C=C1)N=C(O2)NCC3CCNC3.C(=O)O

SLB1122168 formic is a potent Spns2-mediated S1P release inhibitor with an IC50 of 94 nM[1].
SLB1122168 (33p; 10 mg/kg; i.p.; once) results in a dose-dependent decrease in circulating lymphocytes[1].
In rats, at 10 mg/kg, SLB1122168 (33p) achieves a maximum concentration of 4 μM at 2 h post-dose with levels at ≥1 μM for 24 h and a half-life of 8 h[1].

Reference

[1]. Ariel L Burgio, et al. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem. 2023 Apr 27;66(8):5873-5891.
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