For research use only. Not for therapeutic Use.
SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
SLC26A3-IN-2 (compound 3a) (10 μM; 10 min) produces 92% inhibition rate against SLC26A3[1].
SLC26A3-IN-2 (10 mg/kg; po) significantly increases stool weight and number of pellets in a Loperamide (HY-B0418A)-induced model of constipation in mice, demonstrating its efficacy in increasing stool hydration in mice[1].
| Catalog Number | I041308 |
| CAS Number | 950348-60-4 |
| Synonyms | 7-[(2-chlorophenoxy)methyl]-3-phenyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
| Molecular Formula | C19H13ClN2O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H13ClN2O2S/c20-15-8-4-5-9-17(15)24-11-14-10-18(23)22-16(12-25-19(22)21-14)13-6-2-1-3-7-13/h1-10,12H,11H2 |
| InChIKey | MXPJASIJFFIVEL-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CSC3=NC(=CC(=O)N23)COC4=CC=CC=C4Cl |
| Reference | [1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149. |
