SLF-amido-C2-COOH

• CAT Number: I019944
• CAS Number: 1092369-24-8
• Molecular Formula: C₃₄H₄₄N₂O₉
• Molecular Weight: 624.72
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 4-[3-[(1R)-3-(3,4-dimethoxyphenyl)-1-[(2S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carbonyl]oxypropyl]anilino]-4-oxobutanoic acid
• InChI: InChI=1S/C34H44N2O9/c1-6-34(2,3)31(40)32(41)36-19-8-7-12-25(36)33(42)45-26(15-13-22-14-16-27(43-4)28(20-22)44-5)23-10-9-11-24(21-23)35-29(37)17-18-30(38)39/h9-11,14,16,20-21,25-26H,6-8,12-13,15,17-19H2,1-5H3,(H,35,37)(H,38,39)/t25-,26+/m0/s1
• InChIKey: FTAKPNRZIJEFIG-IZZNHLLZSA-N
• SMILES: CCC(C)(C)C(=O)C(=O)N1CCCCC1C(=O)OC(CCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)NC(=O)CCC(=O)O

SLF-amido-C2-COOH（Cat No.:I019944）, also known as PROTAC FKBP12-binding moiety 1, is a synthetic ligand designed to selectively bind to FKBP12 protein. It serves as a component in the synthesis of PROTAC molecules, which are bifunctional compounds capable of targeted protein degradation. SLF-amido-C2-COOH acts as the ligand responsible for binding to FKBP12, while the other end of the PROTAC molecule binds to the target protein of interest. This synthetic ligand enables the development of PROTACs as a strategy for modulating protein levels and biological pathways.

Reference

[1]. Dunyak BM, et al. Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of TwoIntracellular Proteins. ACS Chem Biol. 2015 Nov 20;10(11):2441-7.