For research use only. Not for therapeutic Use.
SLM6 is an inhibitor of cyclin-dependent kinase-9 (CDK9). It exhibits potent anti-multiple myeloma activity.
| Catalog Number | I036380 |
| CAS Number | 22242-91-7 |
| Synonyms | SLM6; SLM-6; SLM 6; Sangivamycin-Like Molecule 6; NSC-107517; NSC 107517; NSC107517; |
| Molecular Formula | C12H17N7O4 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbohydrazonamide |
| InChI | InChI=1S/C12H17N7O4/c13-9(18-15)4-1-19(11-6(4)10(14)16-3-17-11)12-8(22)7(21)5(2-20)23-12/h1,3,5,7-8,12,20-22H,2,15H2,(H2,13,18)(H2,14,16,17)/t5-,7-,8-,12-/m1/s1 |
| InChIKey | WAMOLHIDNBDQSK-JTFADIMSSA-N |
| SMILES | N/C(C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=NC=NC(N)=C31)=NN |
| Reference | 1: Dolloff NG, Allen JE, Dicker DT, Aqui N, Vogl D, Malysz J, Talamo G, El-Deiry WS. Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. Mol Cancer Ther. 2012 Nov;11(11):2321-30. doi: 10.1158/1535-7163.MCT-12-0578. Epub 2012 Sep 10. PubMed PMID: 22964485; PubMed Central PMCID: PMC3502072. |
