SLMP53-1

For research use only. Not for therapeutic Use.

  • CAT Number: I043475
  • CAS Number: 1643469-17-3
  • Molecular Formula: C20H18N2O2
  • Molecular Weight: 318.37
  • Purity: ≥95%
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SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].


Catalog Number I043475
CAS Number 1643469-17-3
Synonyms

(3S,9bR)-3-(1H-indol-3-ylmethyl)-9b-methyl-2,3-dihydro-[1,3]oxazolo[2,3-a]isoindol-5-one

Molecular Formula C20H18N2O2
Purity ≥95%
InChI InChI=1S/C20H18N2O2/c1-20-17-8-4-2-7-16(17)19(23)22(20)14(12-24-20)10-13-11-21-18-9-5-3-6-15(13)18/h2-9,11,14,21H,10,12H2,1H3/t14-,20+/m0/s1
InChIKey RSAFMLBHKXOCJG-VBKZILBWSA-N
SMILES CC12C3=CC=CC=C3C(=O)N1C(CO2)CC4=CNC5=CC=CC=C54
Reference

[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.
 [Content Brief]

[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596.
 [Content Brief]

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