For research use only. Not for therapeutic Use.
SEL-201 ( Cat No. : I020045 ), also known as SLV-2436, SEL201-88, is a potent and ATP-competitive MNK1 and MNK2 inhibitor with IC50 values of 10.8 nM and 5.4 nM, respectively. If you need, please feel free to contact us, we will reply you within 24 hours.
| Catalog Number | I020045 |
| CAS Number | 2095704-43-9 |
| Molecular Formula | C₁₉H₁₅ClN₄O |
| Purity | ≥95% |
| Target | MNK |
| Storage | Store at -20°C |
| IUPAC Name | 5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one |
| InChI | InChI=1S/C19H15ClN4O/c20-15-3-1-2-12(8-15)10-24-11-14(5-7-18(24)25)13-4-6-16-17(9-13)22-23-19(16)21/h1-9,11H,10H2,(H3,21,22,23) |
| InChIKey | YQVUADHJKWJHAF-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)CN2C=C(C=CC2=O)C3=CC4=C(C=C3)C(=NN4)N |
| Reference | [1]. Zhan Y, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017 Nov 1;127(11):4179-4192. |
