SIS3

• CAT Number: I003897
• CAS Number: 521984-48-5
• Molecular Formula: C₂₈H₂₇N₃O₃ ∙ HCl
• Molecular Weight: 489.99
• Purity: ≥95%
• Synonyms: (E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride
• Target: SMAD
• Solubility: DMSO ≥ 30 mg/mL
• Storage: Store at -20C
• IUPAC Name: (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride
• InChI: InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+
• InChIKey: CDKIEBFIMCSCBB-CALJPSDSSA-N
• SMILES: CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl

SIS3（Cat No.:I003897）is a high-purity, selective inhibitor of the Smad3 protein, essential for advanced biomedical and pharmaceutical research. This compound is crucial for studies involving TGF-β signaling pathways, fibrosis, and cancer research. By specifically inhibiting Smad3, SIS3 helps in elucidating the role of Smad3 in cellular processes and disease mechanisms. Its consistent quality ensures precise and reliable experimental results, enhancing the accuracy of data. Ideal for various research applications, SIS3 integrates seamlessly into existing protocols, offering a robust and cost-effective solution for high-precision scientific investigations and drug development.