SMARCA-BD ligand 1 for Protac dihydrochloride

• CAT Number: I018267
• CAS Number: 2369053-68-7
• Molecular Formula: C14H19Cl2N5O
• Molecular Weight: 344.24
• Purity: ≥95%
• Synonyms: 2-(6-amino-5-piperazin-1-ylpyridazin-3-yl)phenol;dihydrochloride
• InChI: InChI=1S/C14H17N5O.2ClH/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20;;/h1-4,9,16,20H,5-8H2,(H2,15,18);2*1H
• InChIKey: INBBYNMFULAIMY-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=CC(=NN=C2N)C3=CC=CC=C3O.Cl.Cl

SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

Reference

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
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