SMARCA-BD ligand 1 for Protac

• CAT Number: I018268
• CAS Number: 1997319-92-2
• Molecular Formula: C₁₄H₁₇N₅O
• Molecular Weight: 271.32
• Purity: ≥95%
• Target: Ligands for Target Protein for PROTAC
• IUPAC Name: 2-(6-amino-5-piperazin-1-ylpyridazin-3-yl)phenol
• InChI: InChI=1S/C14H17N5O/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20/h1-4,9,16,20H,5-8H2,(H2,15,18)
• InChIKey: SZKHGLTYXIDOFH-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=CC(=NN=C2N)C3=CC=CC=C3O

SMARCA-BD ligand 1（Cat No.:I018268）is a ligand used in the development of PROTACs (Proteolysis Targeting Chimeras), a class of small molecules designed to target specific proteins for degradation via the ubiquitin-proteasome system. SMARCA-BD ligand 1 targets the bromodomain (BD) of SMARCA proteins, which are involved in chromatin remodeling and gene expression regulation. By recruiting the target protein to an E3 ligase, SMARCA-BD ligand 1 facilitates its ubiquitination and subsequent degradation. This approach is useful in drug discovery for eliminating disease-causing proteins, particularly in cancer and other disorders driven by dysregulated gene expression.