SMER28

• CAT Number: I003088
• CAS Number: 307538-42-7
• Molecular Formula: C11H10BrN3
• Molecular Weight: 264.12
• Purity: ≥95%
• Synonyms: N-allyl-6-bromoquinazolin-4-amine
• Target: Autophagy
• Solubility: DMSO ≥ 32 mg/mL
• Storage: 2-8°C
• IUPAC Name: 6-bromo-N-prop-2-enylquinazolin-4-amine
• InChI: InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
• InChIKey: BCPOLXUSCUFDGE-UHFFFAOYSA-N
• SMILES: C=CCNC1=NC=NC2=C1C=C(C=C2)Br

SMER28（Cat No.:I003088） is a small molecule compound that modulates autophagy, a cellular process involved in the degradation and recycling of cellular components. Unlike many autophagy modulators that act through the mTOR pathway, SMER28 exerts its effects via an mTOR-independent mechanism. It has been shown to prevent the accumulation of amyloid beta peptide, a hallmark of Alzheimer’s disease. By activating autophagy, SMER28 holds potential as a therapeutic agent for neurodegenerative disorders associated with impaired autophagy and protein accumulation.

Reference

[1]. Renna M et al. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J Biol Chem. 2010 Apr 9;285(15):11061-7.

[2]. Shen D et al. Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodies. Cell Biochem Biophys. 2011 Jul;60(3):173-85.

[3]. Tian Y et al. A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway. FASEB J. 2011 Jun;25(6):1934-42.