SMI-4a

• CAT Number: I003157
• CAS Number: 327033-36-3
• Molecular Formula: C₁₁H₆F₃NO₂S
• Molecular Weight: 273.23
• Purity: ≥95%
• Target: Pim
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: (5E)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5+
• InChIKey: NGJLOFCOEOHFKQ-VMPITWQZSA-N
• SMILES: C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2

SMI-4a (Cat No.: I003157) is a potent pan-Pim kinase inhibitor that also acts to block mTORC1 activity through the activation of AMPK. This dual mechanism of action is of significant interest in cancer research. SMI-4a, specifically under the designation TCS-PIM-1-4a, demonstrates cytotoxicity against various myeloid and lymphoid cell lines, with IC50 values ranging from 0.8 μM to 40 μM. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Lin YW, Beharry ZM, Hill EG, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33.
[2]. Beharry Z, Mahajan S, Zemskova M,et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108(2):528-33.
[3]. Benoit SR, Ji M, Fleming R,et al . Predictors of dropouts from a San Diego diabetes program: a case control study. Prev Chronic Dis. 2004:1(4):A10.
[4]. Zuping Xia, Christian Knaak, Jian Ma et al. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases. J. Med. Chem., 2009, 52 (1), pp 74-86